Withdrawal reasons of randomized controlled trials on type 2 diabetes: a systematic review.

ABSTRACT:

Purpose

Type 2 diabetes mellitus (T2DM) is the subject of numerous randomized controlled trials (RCTs). The validity of RCTs may be threatened by attrition bias due to the discontinuation of the study. The aim of this systematic review is to evaluate the reasons of patient's withdrawal from these RCTs.

Methods

A systematic literature search on PubMed, Cochrane Library, Web of Science, and Scopus databases was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram. The aim was to obtain all relevant blinded RCTs published before January 2017 in which the effectiveness of synthetic drugs, vitamins/minerals were compared to that of placebo or active control in T2DM. The quality of RCTs was assessed using the Jad

SUBMITTER: Mohseni S 

PROVIDER: S-EPMC8149490 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature