The baroreflex afferent pathway plays a critical role in H₂S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions.

ABSTRACT: Hydrogen sulfide (H₂S), which is closely related to various cardiovascular disorders, lowers blood pressure (BP), but whether this action is mediated via the modification of baroreflex afferent function has not been elucidated. Therefore, the current study aimed to investigate the role of the baroreflex afferent pathway in H₂S-mediated autonomic control of BP regulation. The results showed that baroreflex sensitivity (BRS) was increased by acute intravenous NaHS (a H₂S donor) administration to renovascular hypertensive (RVH) and control rats. Molecular expression data also showed that the expression levels of critical enzymes related to H₂S were aberrantly downregulated in the nodose ganglion (NG) and nucleus tractus solitarius (NTS) in RVH rats.

SUBMITTER: Li Y 

PROVIDER: S-EPMC8149652 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature