Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis.
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ABSTRACT:
SUBMITTER: Schregel K
PROVIDER: S-EPMC8149750 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis.
Schregel Katharina K Baufeld Caroline C Palotai Miklos M Meroni Roberta R Fiorina Paolo P Wuerfel Jens J Sinkus Ralph R Zhang Yong-Zhi YZ McDannold Nathan N White P Jason PJ Guttmann Charles R G CRG
Frontiers in neuroscience 20210512
Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis (MS). EAE reflects important histopathological hallmarks, dissemination, and diversity of the disease, but has only moderate reproducibility of clinical and histopathological features. Focal lesions are less frequently observed in EAE than in MS, and can neither be constrained to specific locations nor timed to occur at a pre-specified moment. This renders difficult any experimental assessment of the pathogenesis of ...[more]
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