Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages.

ABSTRACT: Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for tissue homeostasis. Professional phagocytes express a plethora of surface receptors enabling them to sense and engulf apoptotic cells, thus avoiding persistence of dead cells and cellular debris and their consequent effects. Dysregulation of efferocytosis is thought to lead to secondary necrosis and associated inflammation and immune activation. Efferocytosis in primarily murine macrophages and dendritic cells has been shown to require TAM RTKs, with MERTK and AXL being critical for clearance of apoptotic cells. The functional role of human orthologs, especially the exact contribution of each individual receptor is less well studied. Here we show that human macrophages differentiated in vitro from

SUBMITTER: Wanke F 

PROVIDER: S-EPMC8149813 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature