Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs.

ABSTRACT: Recent single-cell studies have revealed that yeast stress response involves transcription factors that are activated in pulses. However, it remains unclear whether and how these dynamic transcription factors temporally interact to regulate stress survival. Here we show that budding yeast cells can exploit the temporal relationship between paralogous general stress regulators, Msn2 and Msn4, during stress response. We find that individual pulses of Msn2 and Msn4 are largely redundant, and cells can enhance the expression of their shared targets by increasing their temporal divergence. Thus, functional redundancy between these two paralogs is modulated in a dynamic manner to confer fitness advantages for yeast cells, which might feed back to promote the preservation of their redundancy. Thi

SUBMITTER: Wu Y 

PROVIDER: S-EPMC8149833 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature