Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit.

ABSTRACT: We investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory. To simplify the analysis, we used a log-linear mortality estimate from the CBC variables as a single quantitative measure of the aging process, henceforth referred to as dynamic organism state indicator (DOSI). We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 - 150 years of age corresponding to a complete loss of resilience.

SUBMITTER: Pyrkov TV 

PROVIDER: S-EPMC8149842 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature