Conventional Type 1 Dendritic Cells (cDC1) in Human Kidney Diseases: Clinico-Pathological Correlations.

ABSTRACT:

Background

cDC1 is a subset of conventional DCs, whose most recognized function is cross-presentation to CD8⁺ T cells. We conducted this study to investigate the number and location of cDC1s in various human kidney diseases as well as their correlation with clinico-pathological features and CD8⁺ T cells.

Methods

We analyzed 135 kidney biopsies samples. Kidney diseases included: acute tubular necrosis (ATN), acute interstitial nephritis (AIN), proliferative glomerulonephritis (GN) (IgA nephropathy, lupus nephritis, pauci-immune GN, anti-GBM disease), non-proliferative GN (minimal change disease, membranous nephropathy) and diabetic nephropathy. Indirect immunofluorescence staining was used to quantify cDC1s, CD1c⁺ DCs, and CD8⁺ T ce

SUBMITTER: Chen T 

PROVIDER: S-EPMC8149958 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature