Different Effects of Leucine Supplementation and/or Exercise on Systemic Insulin Sensitivity in Mice.

ABSTRACT:

Objective

Obesity-related diseases such as diabetes, hypertension, dyslipidemia, and cardiovascular diseases have increased due to the obesity epidemic. Early intervention for obesity through lifestyle and nutrition plays an important role in preventing obesity-related diseases. Therefore, the purpose of this study is to explore the role of leucine and exercise in adiposity, systemic insulin resistance, and inflammation to provide theoretical and guiding basis for the early prevention and treatment of obesity.

Methods

C57BL/6J male mice were randomly divided into HFD or LFD-fed mice group. After 9 weeks, glucose tolerance test (GTT) was performed to detect their systemic insulin sensitivity. Starting from week 10, mice were divided into eight groups and treated with moderate

SUBMITTER: Jiang X 

PROVIDER: S-EPMC8150005 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature