A well-directional three-dimensional DNA walking nanomachine that runs in an orderly manner.

ABSTRACT: Herein, we report a three-dimensional (3D) DNA walking nanomachine innovatively constructed from a functionalized 3D DNA track, which runs in an orderly manner with favorable directionality to allow for programming certain pathways of information transduction for some target tasks. The nanomachine was constructed using a departure station of walker (U^B + W) and a functionalized 3D track, which was made up of a rolling circle amplification (RCA)-generated backbone chain and numerous triangular rung units with stators (U^A + S) assembled into a repeating array along the backbone. A specific domain (SD) was designed at the 5'-end of the backbone to capture the U^B + W, and stators with specific RNA substrates were immobilized at the three U^A corners f

SUBMITTER: Jiang J 

PROVIDER: S-EPMC8150096 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature