Ontology highlight
ABSTRACT:
SUBMITTER: Zuo L
PROVIDER: S-EPMC8150104 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Zuo Liping L Ding Jingjing J Li Changkun C Lin Feng F Chen Peng R PR Wang Peilin P Lu Guihong G Zhang Jinfeng J Huang Li-Li LL Xie Hai-Yan HY
Chemical science 20200113 8
Precise activation of prodrugs in tumor tissues is critical to ensuring specific antitumor efficacy, meanwhile reducing the serious adverse effects. Here, a spatiotemporally controlled prodrug activation strategy was provided by integrating the inverse electron demand Diels-Alder (IEDDA) reaction with two tumor-microenvironment-responsive nanovehicles. The prodrug (Dox-TCO) and [4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methanamine (Tz) were separately camouflaged into low pH and matrix metallopr ...[more]