CATH functional families predict functional sites in proteins.

ABSTRACT:

Motivation

Identification of functional sites in proteins is essential for functional characterization, variant interpretation and drug design. Several methods are available for predicting either a generic functional site, or specific types of functional site. Here, we present FunSite, a machine learning predictor that identifies catalytic, ligand-binding and protein-protein interaction functional sites using features derived from protein sequence and structure, and evolutionary data from CATH functional families (FunFams).

Results

FunSite's prediction performance was rigorously benchmarked using cross-validation and a holdout dataset. FunSite outperformed other publicly available functional site prediction methods. We show that conserved residues in FunFams are enriched in

SUBMITTER: Das S 

PROVIDER: S-EPMC8150129 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature