RNA inter-nucleotide 3D closeness prediction by deep residual neural networks.

ABSTRACT:

Motivation

Recent years have witnessed that the inter-residue contact/distance in proteins could be accurately predicted by deep neural networks, which significantly improve the accuracy of predicted protein structure models. In contrast, fewer studies have been done for the prediction of RNA inter-nucleotide 3D closeness.

Results

We proposed a new algorithm named RNAcontact for the prediction of RNA inter-nucleotide 3D closeness. RNAcontact was built based on the deep residual neural networks. The covariance information from multiple sequence alignments and the predicted secondary structure were used as the input features of the networks. Experiments show that RNAcontact achieves the respective precisions of 0.8 and 0.6 for the top L/10 and L (where L is the length of an RN

SUBMITTER: Sun S 

PROVIDER: S-EPMC8150135 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature