Aluminum and Tau in Neurofibrillary Tangles in Familial Alzheimer's Disease.

ABSTRACT:

Background

Familial Alzheimer's disease (fAD) is driven by genetic predispositions affecting the expression and metabolism of the amyloid-β protein precursor. Aluminum is a non-essential yet biologically-reactive metal implicated in the etiology of AD. Recent research has identified aluminum intricately and unequivocally associated with amyloid-β in senile plaques and, more tentatively, co-deposited with neuropil-like threads in the brains of a Colombian cohort of donors with fAD.

Objective

Herein, we have assessed the co-localization of aluminum to immunolabelled phosphorylated tau to probe the potential preferential binding of aluminum to senile plaques or neurofibrillary tangles in the same Colombian kindred.

Methods

Herein, we have performed phosphorylated tau-spe

SUBMITTER: Mold MJ 

PROVIDER: S-EPMC8150251 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature