Superior Frontal Gyrus TOMM40-APOE Locus DNA Methylation in Alzheimer's Disease.

ABSTRACT:

Background

The APOE ɛ4 allele is the strongest known genetic risk factor for sporadic Alzheimer's disease (AD). The neighboring TOMM40 gene has also been implicated in AD due to its close proximity to APOE.

Objective

Here we tested whether methylation of the TOMM40-APOE locus may influence ApoE protein levels and AD pathology.

Methods

DNA methylation levels across the TOMM40-APOE locus and ApoE levels were measured in superior frontal gyrus tissues of 62 human brains genotyped for APOE and scored for AD neuropathology.

Results

Methylation levels within the TOMM40 CpG island in the promoter or APOE CpG island in Exon 4 did not differ between APOE ɛ4 carriers versus non-carriers. However, APOE

SUBMITTER: Bezuch N 

PROVIDER: S-EPMC8150259 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature