Dataset Information

Atypical presentation of nontuberculous mycobacterial pulmonary infection in a patient with interstitial lung abnormality: A case report.

ABSTRACT: Nontuberculous mycobacterial (NTM) infection is a common and important cause of chronic pulmonary disease, typically characterized by fibrocavitary and nodular-bronchiectatic forms on computed tomography (CT) of the chest. Structural lung disease and the host's immune status can affect NTM pulmonary infections. Herein, we report a rare case of an NTM pulmonary infection with multiple nodules and masses (with internal cavitation) in an immunocompetent patient exhibiting interstitial lung abnormality on a chest CT.

SUBMITTER: Park J

PROVIDER: S-EPMC8150260 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Atypical presentation of nontuberculous mycobacterial pulmonary infection in a patient with interstitial lung abnormality: A case report.

Park Jongmin J Park Byunggeon B

European journal of radiology open 20210520

Nontuberculous mycobacterial (NTM) infection is a common and important cause of chronic pulmonary disease, typically characterized by fibrocavitary and nodular-bronchiectatic forms on computed tomography (CT) of the chest. Structural lung disease and the host's immune status can affect NTM pulmonary infections. Herein, we report a rare case of an NTM pulmonary infection with multiple nodules and masses (with internal cavitation) in an immunocompetent patient exhibiting interstitial lung abnormal ...[more]

PMID: 34056053

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Project description:BackgroundThe role of bacterial microbiota in the pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM-PD) is unclear. We aimed to compare the bacterial microbiome of disease-invaded lesions and non-invaded lung tissue from NTM-PD patients.MethodsWe analyzed lung tissues from 23 NTM-PD patients who underwent surgical lung resection. Lung tissues were collected in pairs from each patient, with one sample from a disease-involved site and the other from a non-involved site. Lung tissue microbiome libraries were constructed using 16S rRNA gene sequences (V3-V4 regions).ResultsSixteen (70%) patients had Mycobacterium avium complex (MAC)-PD, and the remaining seven (30%) had Mycobacterium abscessus-PD. Compared to non-involved sites, involved sites showed greater species richness (ACE, Chao1, and Jackknife analyses, all p = 0.001); greater diversity on the Shannon index (p = 0.007); and genus-level differences (Jensen-Shannon, PERMANOVA p = 0.001). Analysis of taxonomic biomarkers using linear discriminant analysis (LDA) effect sizes (LEfSe) demonstrated that several genera, including Limnohabitans, Rahnella, Lachnospira, Flavobacterium, Megamonas, Gaiella, Subdoligranulum, Rheinheimera, Dorea, Collinsella, and Phascolarctobacterium, had significantly greater abundance in involved sites (LDA >3.00, p <0.05, and q <0.05). In contrast, Acinetobacter had significantly greater abundance at non-involved sites (LDA = 4.27, p<0.001, and q = 0.002). Several genera were differentially distributed between lung tissues from MAC-PD (n = 16) and M. abscessus-PD (n = 7), and between nodular bronchiectatic form (n = 12) and fibrocavitary form (n = 11) patients. However, there was no genus with a significant q-value.ConclusionsWe identified differential microbial distributions between disease-invaded and normal lung tissues from NTM-PD patients, and microbial diversity was significantly higher in disease-invaded tissues.Trial registrationClinical Trial registration number: NCT00970801.

Dataset Information

Atypical presentation of nontuberculous mycobacterial pulmonary infection in a patient with interstitial lung abnormality: A case report.

Publications

Atypical presentation of nontuberculous mycobacterial pulmonary infection in a patient with interstitial lung abnormality: A case report.

Similar Datasets

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