Follicle stimulating hormone and estradiol alter immune response in osteoarthritic mice in an opposite manner.

ABSTRACT: Although a number of studies have shown that the occurrence and progression of osteoarthritis (OA) is related to endocrine system dysfunction, there is limited evidence about what roles sex hormones play. The aim of the present study was to examine the capacity of 17β-estradiol (ED) and follicle stimulating hormone (FSH) to alter the differentiation of bone marrow (BM) cells in arthritic mice. The experiments were conducted in collagenase-induced osteoarthritis in mice. Cartilage degradation was observed by safranin and toluidine blue staining. Flow cytometry was used to define different BM and synovial cell populations. The influence of FSH and ED on osteoclastogenesis was studied in BM cultures and on the osteoblastogenesis in primary calvarial cultures. The levels of IL-8, TNF-α, FSH, a

SUBMITTER: Belenska-Todorova L 

PROVIDER: S-EPMC8150452 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature