Oral Dysbiosis and Inflammation in Parkinson's Disease.

ABSTRACT:

Background

Oral microbiota has largely escaped attention in Parkinson's disease (PD), despite its pivotal role in maintaining oral and systemic health.

Objective

The aim of our study was to examine the composition of the oral microbiota and the degree of oral inflammation in PD.

Methods

Twenty PD patients were compared to 20 healthy controls. Neurological, periodontal and dental examinations were performed as well as dental scaling and gingival crevicular fluid sampling for cytokines measurement (interleukine (IL)-1β, IL-6, IL-1 receptor antagonist (RA), interferon-γ and tumor necrosis factor (TNF)-α). Two months later, oral microbiota was sampled from saliva and subgingival dental plaque. A 16S rRNA gene amplicon sequencing was used to assess bacterial communities.

SUBMITTER: Fleury V 

PROVIDER: S-EPMC8150470 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature