Parkinson's Disease Subtypes: Critical Appraisal and Recommendations.

ABSTRACT:

Background

In Parkinson's disease (PD), there is heterogeneity in the clinical presentation and underlying biology. Research on PD subtypes aims to understand this heterogeneity with potential contribution for the knowledge of disease pathophysiology, natural history and therapeutic development. There have been many studies of PD subtypes but their impact remains unclear with limited application in research or clinical practice.

Objective

To critically evaluate PD subtyping systems.

Methods

We conducted a systematic review of PD subtypes, assessing the characteristics of the studies reporting a subtyping system for the first time. We completed a critical appraisal of their methodologic quality and clinical applicability using standardized checklists.

Results

We

SUBMITTER: Mestre TA 

PROVIDER: S-EPMC8150501 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature