Clinical Markers of Chronic Hypoxemia in Respiratory Patients Residing at Moderate Altitude.

ABSTRACT: Supplemental oxygen (SO) increases survival in hypoxemic patients. In hypoxia, mammals respond by modulating O₂-sensitive transducers that stabilize the transcription factor hypoxia-inducible factor-1-alpha (HIF-1α), which transactivates the genes that govern angiogenesis and metabolic pathways. Residing at high altitudes exposes millions of people to hypoxemia with potential adverse consequences on their health. We aimed to identify markers of hypoxemia that can be used in the evaluation of patients in addition to pulse oximetry and arterial blood gases, especially those that could respond after 1 month of oxygen use. We performed a prospective pilot study at 2240 m above sea level, with repeated measurements before and after (b/a) 1-month home oxygen therapy in 70 patients wit

SUBMITTER: Fernandez-Plata R 

PROVIDER: S-EPMC8150591 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature