Plasma Protein Biomarkers Associated with Higher Ovarian Cancer Risk in BRCA1/2 Carriers.

ABSTRACT: Ovarian cancer (OC) is the most lethal gynecologic malignancy and in-time diagnosis is limited because of the absence of effective biomarkers. Germline BRCA1/2 genetic alterations are risk factors for hereditary OC; risk-reducing salpingo-oophorectomy (RRSO) is pursued for disease prevention. However, not all healthy carriers develop the disease. Therefore, identifying predictive markers in the BRCA1/2 carrier population could help improve the identification of candidates for preventive RRSO. In this study, plasma samples from 20 OC patients (10 patients with BRCA1/2 wild type (_wt) and 10 with the BRCA1/2 variant (_var)) and 20 normal subjects (10 subjects with BRCA1/2_wt and 10 with BRCA1/2_var) were analyz

SUBMITTER: Ahn HS 

PROVIDER: S-EPMC8150736 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature