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Preparation of the Key Dolutegravir Intermediate via MgBr2-Promoted Cyclization.

ABSTRACT: A novel approach for synthesizing the key dolutegravir intermediate is described via MgBr2-promoted intramolecular cyclization. Condensation of commercially available methyl oxalyl chloride and ethyl 3-(N,N-dimethylamino)acrylate afforded the vinylogous amide in an excellent yield. Subsequent substitution by aminoacetaldehyde dimethyl acetal and methyl bromoacetate gave rise to the expected precursor for cyclization, which was promoted by MgBr2 to highly selectively convert into pyridinone diester. The key dolutegravir intermediate was finally prepared by the selective hydrolysis of the corresponding diester via LiOH.

SUBMITTER: Kong J

PROVIDER: S-EPMC8150840 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Preparation of the Key Dolutegravir Intermediate via MgBr2-Promoted Cyclization.

Kong Jiahui J Xia Haijian H He Renbao R Chen Hao H Yu Yongping Y

Molecules (Basel, Switzerland) 20210511 10

A novel approach for synthesizing the key dolutegravir intermediate is described via MgBr2-promoted intramolecular cyclization. Condensation of commercially available methyl oxalyl chloride and ethyl 3-(N,N-dimethylamino)acrylate afforded the vinylogous amide in an excellent yield. Subsequent substitution by aminoacetaldehyde dimethyl acetal and methyl bromoacetate gave rise to the expected precursor for cyclization, which was promoted by MgBr2 to highly selec ...[more]

PMID: 34064812

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