A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease.

ABSTRACT: The central role mitochondria play in cellular homeostasis has made its study critical to our understanding of various aspects of human health and disease. Mitochondria rely on the translocase of the outer membrane (TOM) complex for the bulk of mitochondrial protein import. In addition to its role as the major entry point for mitochondrial proteins, the TOM complex serves as an entry pathway for viral proteins. TOM complex subunits also participate in a host of interactions that have been studied extensively for their function in neurodegenerative diseases, cardiovascular diseases, innate immunity, cancer, metabolism, mitophagy and autophagy. Recent advances in our structural understanding of the TOM complex and the protein import machinery of the outer mitochondrial membrane have made str

SUBMITTER: Pitt AS 

PROVIDER: S-EPMC8150904 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature