Cerebroprotective effect of pterostilbene against global cerebral ischemia in rats.

ABSTRACT:

Aim of the study

The role of pterostilbene against induced neurobehavioral alterations in global cerebral ischemia-reperfusion and oxidative damage was studied.

Materials and methods

Male SD rats (180-200 g) were exposed for 30 min to bilateral carotid artery occlusion accompanied by 60 min reperfusion to cause cerebral injury. Pretreatment with pterostilbene (200 and 400 mg/kg, orally) was given to the animals for ten days followed by ischemia-reperfusion injury. Various behavioral tests (locomotor activity, neurological score, transfer latency, hanging wire test) were studied. The brain tissues of animals were used for both the biochemical parameters (lipid peroxidation, reduced glutathione, superoxide dismutase, catalase activity) and histopathological study.

Result

SUBMITTER: Khan MM 

PROVIDER: S-EPMC8150920 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature