Assessing the Protective Dose of a Candidate DIVA Vaccine against Classical Swine Fever.

ABSTRACT: Classical swine fever is a highly contagious and deadly disease in swine. The disease can be controlled effectively by vaccination with an attenuated virus known as the "Chinese" (C)-strain. A single vaccination with the C-strain provides complete protection against highly virulent isolates within days after vaccination, making it one of the most efficacious veterinary vaccines ever developed. A disadvantage of the C-strain is that vaccinated animals cannot be serologically differentiated from animals that are infected with wild-type Classical swine fever virus. Previously, a C-strain-based vaccine with a stable deletion in the E2 structural glycoprotein was developed, which allows for differentiation between infected and vaccinated animals (DIVA). The resulting vaccine, which we named C-D

SUBMITTER: Jelsma T 

PROVIDER: S-EPMC8151196 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature