Angiogenic CD34 Stem Cell Therapy in Coronary Microvascular Repair-A Systematic Review.

ABSTRACT: Ischemia with non-obstructive coronary arteries (INOCA) is an increasingly recognized disease, with a prevalence of 3 to 4 million individuals, and is associated with a higher risk of morbidity, mortality, and a worse quality of life. Persistent angina in many patients with INOCA is due to coronary microvascular dysfunction (CMD), which can be difficult to diagnose and treat. A coronary flow reserve <2.5 is used to diagnose endothelial-independent CMD. Antianginal treatments are often ineffective in endothelial-independent CMD and thus novel treatment modalities are currently being studied for safety and efficacy. CD34⁺ cell therapy is a promising treatment option for these patients, as it has been shown to promote vascular repair and enhance angiogenesis in the microvasculature

SUBMITTER: Rai B 

PROVIDER: S-EPMC8151216 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature