Evidence of Cooperation between Hippo Pathway and RAS Mutation in Thyroid Carcinomas.

ABSTRACT: Thyroid cancer incidences have been steadily increasing worldwide and are projected to become the fourth leading cancer diagnosis by 2030. Improved diagnosis and prognosis predictions for this type of cancer depend on understanding its genetic bases and disease biology. RAS mutations have been found in a wide range of thyroid tumors, from benign to aggressive thyroid carcinomas. Based on that and in vivo studies, it has been suggested that RAS cooperates with other driver mutations to induce tumorigenesis. This study aims to identify genetic alterations or pathways that cooperate with the RAS mutation in the pathogenesis of thyroid cancer. From a cohort of 120 thyroid carcinomas, 11 RAS-mutated samples were identified. The samples were subjected to RNA-Sequencin

SUBMITTER: Carneiro TNR 

PROVIDER: S-EPMC8151534 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature