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Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial.

ABSTRACT:

SUBMITTER: Sharman JP

PROVIDER: S-EPMC8151619 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial.

Sharman Jeff P JP Egyed Miklos M Jurczak Wojciech W Skarbnik Alan A Pagel John M JM Flinn Ian W IW Kamdar Manali M Munir Talha T Walewska Renata R Corbett Gillian G Fogliatto Laura Maria LM Herishanu Yair Y Banerji Versha V Coutre Steven S Follows George G Walker Patricia P Karlsson Karin K Ghia Paolo P Janssens Ann A Cymbalista Florence F Woyach Jennifer A JA Salles Gilles G Wierda William G WG Izumi Raquel R Munugalavadla Veerendra V Patel Priti P Wang Min Hui MH Wong Sofia S Byrd John C JC

Lancet (London, England) 20200401 10232

<h4>Background</h4>Acalabrutinib is a selective, covalent Bruton tyrosine-kinase inhibitor with activity in chronic lymphocytic leukaemia. We compare the efficacy of acalabrutinib with or without obinutuzumab against chlorambucil with obinutuzumab in patients with treatment-naive chronic lymphocytic leukaemia.<h4>Methods</h4>ELEVATE TN is a global, phase 3, multicentre, open-label study in patients with treatment-naive chronic lymphocytic leukaemia done at 142 academic and community hospitals in ...[more]

PMID: 32305093

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Correction: Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in treatment-naive chronic lymphocytic leukemia.

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