Survey of the Transcription Factor Responses of Mouse Lung Alveolar Macrophages to Pneumocystis murina.

ABSTRACT: Pneumocystis jirovecii is a fungal pathogen that can cause life-threatening infections in individuals who are immunocompromised. Acquired via inhalation, upon entering the respiratory tract, the fungi first encounter innate immune cells such as alveolar macrophages (AMs). Relatively little is known about the AM cellular responses to the organism, and particularly transcription factor (TF) profiles leading to early host responses during infection. Utilizing the Mouse Transcription Factors RT2 Profiler™ PCR Array, we report an initial TF survey of these macrophage and Pneumocystis interactions. Expression levels of a panel of mouse TFs were compared between unstimulated and Pneumocystis murina-stimulated AMs. Interestingly, a number of TFs previously implicated in pathogen-host cell interact

SUBMITTER: Kottom TJ 

PROVIDER: S-EPMC8151842 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature