Ontology highlight
ABSTRACT:
SUBMITTER: Mantri CK
PROVIDER: S-EPMC8152039 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Mantri Chinmay Kumar CK Soundarajan Gayathri G Saron Wilfried A A WAA Rathore Abhay P S APS Alonso Sylvie S St John Ashley L AL
Viruses 20210512 5
Sub-neutralizing concentrations of antibodies in dengue infected patients is a major risk factor for the development of dengue hemorrhagic fever and dengue shock syndrome. Here, we describe a mouse model with a deficiency in mast cells (MCs) in addition to a deficiency in Type-I and II IFN receptors for studying dengue virus (DENV) infection. We used this model to understand the influence of MCs in a maternal antibody-dependent model of severe dengue, where offspring born to DENV-immune mothers ...[more]