Genetic diversity and population structure of Plasmodium falciparum in Nigeria: insights from microsatellite loci analysis.

ABSTRACT:

Background

Malaria remains a public health burden especially in Nigeria. To develop new malaria control and elimination strategies or refine existing ones, understanding parasite population diversity and transmission patterns is crucial.

Methods

In this study, characterization of the parasite diversity and structure of Plasmodium falciparum isolates from 633 dried blood spot samples in Nigeria was carried out using 12 microsatellite loci of P. falciparum. These microsatellite loci were amplified via semi-nested polymerase chain reaction (PCR) and fragments were analysed using population genetic tools.

Results

Estimates of parasite genetic diversity, such as mean number of different alleles (13.52), effective alleles (7.13), allelic richness (11.15) and expected hetero

SUBMITTER: Ajogbasile FV 

PROVIDER: S-EPMC8152046 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature