High Glucose Shifts the Oxylipin Profiles in the Astrocytes towards Pro-Inflammatory States.

ABSTRACT: Hyperglycemia is associated with several complications in the brain, which are also characterized by inflammatory conditions. Astrocytes are responsible for glucose metabolism in the brain and are also important participants of inflammatory responses. Oxylipins are lipid mediators, derived from the metabolism of polyunsaturated fatty acids (PUFAs) and are generally considered to be a link between metabolic and inflammatory processes. High glucose exposure causes astrocyte dysregulation, but its effects on the metabolism of oxylipins are relatively unknown and therefore, constituted the focus of our work. We used normal glucose (NG, 5.5 mM) vs. high glucose (HG, 25 mM) feeding media in primary rat astrocytes-enriched cultures and measured the extracellular release of oxylipins (UPLC-MS/MS)

SUBMITTER: Chistyakov DV 

PROVIDER: S-EPMC8152232 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature