GWENA: gene co-expression networks analysis and extended modules characterization in a single Bioconductor package.

ABSTRACT:

Background

Network-based analysis of gene expression through co-expression networks can be used to investigate modular relationships occurring between genes performing different biological functions. An extended description of each of the network modules is therefore a critical step to understand the underlying processes contributing to a disease or a phenotype. Biological integration, topology study and conditions comparison (e.g. wild vs mutant) are the main methods to do so, but to date no tool combines them all into a single pipeline.

Results

Here we present GWENA, a new R package that integrates gene co-expression network construction and whole characterization of the detected modules through gene set enrichment, phenotypic association, hub genes detection, topological

SUBMITTER: Lemoine GG 

PROVIDER: S-EPMC8152313 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature