The surface chemistry of a nanocellulose drug carrier unravelled by MAS-DNP.

ABSTRACT: Cellulose nanofibrils (CNF) are renewable bio-based materials with high specific area, which makes them ideal candidates for multiple emerging applications including for instance on-demand drug release. However, in-depth chemical and structural characterization of the CNF surface chemistry is still an open challenge, especially for low weight percentage of functionalization. This currently prevents the development of efficient, cost-effective and reproducible green synthetic routes and thus the widespread development of targeted and responsive drug-delivery CNF carriers. We show in this work how we use dynamic nuclear polarization (DNP) to overcome the sensitivity limitation of conventional solid-state NMR and gain insight into the surface chemistry of drug-functionalized TEMPO-oxidized ce

SUBMITTER: Kumar A 

PROVIDER: S-EPMC8152408 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature