CD73⁺ Mesenchymal Stem Cells Ameliorate Myocardial Infarction by Promoting Angiogenesis.

ABSTRACT: With multipotent differentiation potential and paracrine capacity, mesenchymal stem cells (MSCs) have been widely applied in clinical practice for the treatment of ischemic heart disease. MSCs are a heterogeneous population and the specific population of MSCs may exhibit a selective ability for tissue repair. The aim of our research was to adapt the CD73⁺ subgroup of adipose derived MSCs (AD-MSCs) for the therapy of myocardial infarction (MI). In this research, AD-MSCs were isolated from adipose tissue surrounding the groin of mice and CD73⁺ AD-MSCs were sorted using flow cytometry. To investigate the therapeutic effects of CD73⁺ AD-MSCs, 1.2 × 10⁶ CD73⁺ AD-MSCs were transplanted into rat model of MI, and CD73^- AD-MSCs, norm

SUBMITTER: Li Q 

PROVIDER: S-EPMC8152667 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature