Cyto-friendly polymerization at cell surfaces modulates cell fate by clustering cell-surface receptors.

ABSTRACT: Lots of strategies, e.g. using multivalent synthetic polymers, have been developed to control the spatial distribution of cell-surface receptors, thus modulating the cell function and fate in a custom-tailored manner. However, clustering cell-surface receptors via multivalent synthetic polymers is highly dependent on the structure as well as the ligand-density of the polymers, which may impose difficulties on the synthesis of polymers with a high density of ligands. Here, we pioneered the utilization of a cyto-friendly polymerization at the cell surface to cluster cell-surface receptors. As a proof of concept, an anti-CD20 aptamer conjugated macromer was initially synthesized, which was then efficiently and stably introduced onto the Raji cell surface via ligand-recept

SUBMITTER: Qi J 

PROVIDER: S-EPMC8152676 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature