Histopathological Growth Patterns and Survival After Resection of Colorectal Liver Metastasis: An External Validation Study.

ABSTRACT: After resection of colorectal cancer liver metastases (CRLM), 2 main histopathological growth patterns can be observed: a desmoplastic and a nondesmoplastic subtype. The desmoplastic subtype has been associated with superior survival. These findings require external validation. An international multicenter retrospective cohort study was conducted in patients treated surgically for CRLM at 3 tertiary hospitals in the United States and the Netherlands. Determination of histopathological growth patterns was performed on hematoxylin and eosin-stained sections of resected CRLM according to international guidelines. Patients displaying a desmoplastic histopathological phenotype (only desmoplastic growth observed) were compared with patients with a nondesmoplastic phenotype (any nondesmoplastic g

SUBMITTER: Hoppener DJ 

PROVIDER: S-EPMC8152695 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature