Gene expression profiling of hypertrophic cardiomyocytes identifies new players in pathological remodelling.

ABSTRACT:

Aims

Pathological cardiac remodelling is characterized by cardiomyocyte (CM) hypertrophy and fibroblast activation, which can ultimately lead to maladaptive hypertrophy and heart failure (HF). Genome-wide expression analysis on heart tissue has been instrumental for the identification of molecular mechanisms at play. However, these data were based on signals derived from all cardiac cell types. Here, we aimed for a more detailed view on molecular changes driving maladaptive CM hypertrophy to aid in the development of therapies to reverse pathological remodelling.

Methods and results

Utilizing CM-specific reporter mice exposed to pressure overload by transverse aortic banding and CM isolation by flow cytometry, we obtained gene expression profiles of hypertrophic CMs in the m

SUBMITTER: Vigil-Garcia M 

PROVIDER: S-EPMC8152696 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature