Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands.

ABSTRACT: The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.

SUBMITTER: Coban T 

PROVIDER: S-EPMC8152782 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature