Controlling Brain State Prior to Stimulation of Parietal Cortex Prevents Deterioration of Sustained Attention.

ABSTRACT: Sustained attention is a limited resource which declines during daily tasks. Such decay is exacerbated in clinical and aging populations. Inhibition of the intraparietal sulcus (IPS), using low-frequency repetitive transcranial magnetic stimulation (LF-rTMS), can lead to an upregulation of functional communication within the attention network. Attributed to functional compensation for the inhibited node, this boost lasts for tens of minutes poststimulation. Despite the neural change, no behavioral correlate has been found in healthy subjects, a necessary direct evidence of functional compensation. To understand the functional significance of neuromodulatory induced fluctuations on attention, we sought to boost the impact of LF-rTMS to impact behavior. We controlled brain state prior to LF-

SUBMITTER: Edwards G 

PROVIDER: S-EPMC8152938 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature