Interictal Epileptiform Discharges are Task Dependent and are Associated with Lasting Electrocorticographic Changes.

ABSTRACT: The factors that control the occurrence of interictal epileptiform discharges (IEDs) are not well understood. We suspected that this phenomenon reflects an attention-dependent suppression of interictal epileptiform activity. We hypothesized that IEDs would occur less frequently when a subject viewed a task-relevant stimulus compared with viewing a blank screen. Furthermore, IEDs have been shown to impair memory when they occur in certain regions during the encoding or recall phases of a memory task. Although these discharges have a short duration, their impact on memory suggests that they have longer lasting electrophysiological effects. We found that IEDs were associated with an increase in low-frequency power and a change in the balance between low- and high-frequency oscillations for se

SUBMITTER: Meisenhelter S 

PROVIDER: S-EPMC8152941 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature