Neuro-protection and neuro-regeneration of the optic nerve: recent advances and future directions.

ABSTRACT:

Purpose of review

Optic neuropathies refer to a collection of diseases in which retinal ganglion cells (RGCs), the specialized neuron of the retina whose axons make up the optic nerve, are selectively damaged. Blindness secondary to optic neuropathies is irreversible as RGCs do not have the capacity for self-renewal and have a limited capacity for self-repair. Numerous strategies are being developed to either prevent further RGC degeneration or replace the cells that have degenerated. In this review, we aim to discuss known limitations to regeneration in central nervous system (CNS), followed by a discussion of previous, current, and future strategies for optic nerve neuroprotection as well as approaches for neuro-regeneration, with an emphasis on developments in the past two years

SUBMITTER: Gokoffski KK 

PROVIDER: S-EPMC8153234 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature