Multidimensional population activity in an electrically coupled inhibitory circuit in the cerebellar cortex.

ABSTRACT: Inhibitory neurons orchestrate the activity of excitatory neurons and play key roles in circuit function. Although individual interneurons have been studied extensively, little is known about their properties at the population level. Using random-access 3D two-photon microscopy, we imaged local populations of cerebellar Golgi cells (GoCs), which deliver inhibition to granule cells. We show that population activity is organized into multiple modes during spontaneous behaviors. A slow, network-wide common modulation of GoC activity correlates with the level of whisking and locomotion, while faster (<1 s) differential population activity, arising from spatially mixed heterogeneous GoC responses, encodes more precise information. A biologically detailed GoC circuit model reproduced the common

SUBMITTER: Gurnani H 

PROVIDER: S-EPMC8153252 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature