Bridging chromatin structure and function over a range of experimental spatial and temporal scales by molecular modeling.

ABSTRACT: Chromatin structure, dynamics, and function are being intensely investigated by a variety of methods, including microscopy, X-ray diffraction, nuclear magnetic resonance, biochemical crosslinking, chromosome conformation capture, and computation. A range of experimental techniques combined with modeling is clearly valuable to help interpret experimental data and, importantly, generate configurations and mechanisms related to the 3D organization and function of the genome. Contact maps, in particular, as obtained by a variety of chromosome conformation capture methods, are of increasing interest due to their implications on genome structure and regulation on many levels. In this perspective, using seven examples from our group's studies, we illustrate how molecular modeling can help interpr

SUBMITTER: Portillo-Ledesma S 

PROVIDER: S-EPMC8153366 | biostudies-literature | 2020 Mar-Apr

REPOSITORIES: biostudies-literature