Traumatic Brain Injury Exposure Lowers Age of Cognitive Decline in AD and Non-AD Conditions.

ABSTRACT: We aimed to detect the possible accelerating role of previous traumatic brain injury (TBI) exposures on the onset of later cognitive decline assessed across different brain diseases. We analyzed data from the National Alzheimer's Coordinating Center (NACC), which provide information on history of TBI and longitudinal data on cognitive and non-cognitive domains for each available subject. At the time of this investigation, a total of 609 NACC subjects resulted to have a documented history of TBI. We compared subjects with and without a history of previous TBI (of any type) at the time of their first cognitive decline assessment, and termed them, respectively, TBI+ and TBI- subjects. Three hundred and sixty-one TBI+ subjects (229 male/132 female) and 248 TBI- subjects (156 male/92 female) we

SUBMITTER: Iacono D 

PROVIDER: S-EPMC8153372 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature