Fiber-Based Electrochemical Biosensors for Monitoring pH and Transient Neurometabolic Lactate.

ABSTRACT: Developing tools that are able to monitor transient neurochemical dynamics is important to decipher brain chemistry and function. Multifunctional polymer-based fibers have been recently applied to monitor and modulate neural activity. Here, we explore the potential of polymer fibers comprising six graphite-doped electrodes and two microfluidic channels within a flexible polycarbonate body as a platform for sensing pH and neurometabolic lactate. Electrodes were made into potentiometric sensors (responsive to pH) or amperometric sensors (lactate biosensors). The growth of an iridium oxide layer made the fiber electrodes responsive to pH in a physiologically relevant range. Lactate biosensors were fabricated via platinum black growth on the fiber electrode, followed by an enzyme layer, making

SUBMITTER: Booth MA 

PROVIDER: S-EPMC8153388 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature