Specific cortical and subcortical grey matter regions are associated with insomnia severity.

ABSTRACT:

Background

There is an increasing awareness that sleep disturbances are a risk factor for dementia. Prior case-control studies suggested that brain grey matter (GM) changes involving cortical (i.e, prefrontal areas) and subcortical structures (i.e, putamen, thalamus) could be associated with insomnia status. However, it remains unclear whether there is a gradient association between these regions and the severity of insomnia in older adults who could be at risk for dementia. Since depressive symptoms and sleep apnea can both feature insomnia-related factors, can impact brain health and are frequently present in older populations, it is important to include them when studying insomnia. Therefore, our goal was to investigate GM changes associated with insomnia severity in a cohort of

SUBMITTER: Falgas N 

PROVIDER: S-EPMC8153469 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature