Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity.

ABSTRACT: The interplay between fat mass and lean mass within human metabolism is not completely understood. We aimed to identify specific circulating metabolomic profiles associated with these body composition compartments. Cross-sectional analyses were conducted over 236 adults with overweight/obesity from the Satiety Innovation (SATIN) study. Body composition was assessed by dual-energy X-ray absorptiometry. A targeted multiplatform metabolite profiling approach was applied. Associations between 168 circulating metabolites and the body composition measures were assessed using elastic net regression analyses. The accuracy of the multimetabolite weighted models was evaluated using a 10-fold cross-validation approach and the Pearson's correlation coefficients between metabolomic profiles and body co

SUBMITTER: Papandreou C 

PROVIDER: S-EPMC8153621 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature