Pre-Operative Decitabine in Colon Cancer Patients: Analyses on WNT Target Methylation and Expression.

ABSTRACT: DNA hypermethylation is common in colon cancer. Previously, we have shown that methylation of WNT target genes predicts poor prognosis in stage II colon cancer. The primary objective of this study was to assess whether pre-operative treatment with decitabine can decrease methylation and increase the expression of WNT target genes APCDD1, AXIN2 and DKK1 in colon cancer patients. A clinical study was conducted, investigating these potential effects of decitabine in colon cancer patients (DECO). Patients were treated two times with 25 mg/m² decitabine before surgery. Methylation and expression of LINE1 and WNT target genes (primary outcome) and expression of endogenous retroviral genes (secondary outcome) were analysed in pre- and post-treatment tumour s

SUBMITTER: Linnekamp JF 

PROVIDER: S-EPMC8153633 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature