Durable 5-year local control for resected brain metastases with early adjuvant SRS: the effect of timing on intended-field control.

ABSTRACT:

Background

Adjuvant stereotactic radiosurgery (SRS) improves the local control of resected brain metastases (BrM). However, the dependency of long-term outcomes on SRS timing relative to surgery remains unclear.

Methods

Retrospective analysis of patients treated with metastasectomy-plus-adjuvant SRS at Memorial Sloan Kettering Cancer Center (MSK) between 2013 and 2016 was conducted. Kaplan-Meier methodology was used to describe overall survival (OS) and cumulative incidence rates were estimated by type of recurrence, accounting for death as a competing event. Recursive partitioning analysis (RPA) and competing risks regression modeling assessed prognostic variables and associated events of interest.

Results

Two hundred and eighty-two patients with BrM had a median OS

SUBMITTER: Bander ED 

PROVIDER: S-EPMC8153823 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature