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Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe.


ABSTRACT: In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.

SUBMITTER: Benschop KSM 

PROVIDER: S-EPMC8153861 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe.

Benschop Kimberley S M KSM   Broberg Eeva K EK   Hodcroft Emma E   Schmitz Dennis D   Albert Jan J   Baicus Anda A   Bailly Jean-Luc JL   Baldvinsdottir Gudrun G   Berginc Natasa N   Blomqvist Soile S   Böttcher Sindy S   Brytting Mia M   Bujaki Erika E   Cabrerizo Maria M   Celma Cristina C   Cinek Ondrej O   Claas Eric C J ECJ   Cremer Jeroen J   Dean Jonathan J   Dembinski Jennifer L JL   Demchyshyna Iryna I   Diedrich Sabine S   Dudman Susanne S   Dunning Jake J   Dyrdak Robert R   Emmanouil Mary M   Farkas Agnes A   De Gascun Cillian C   Fournier Guillaume G   Georgieva Irina I   Gonzalez-Sanz Ruben R   van Hooydonk-Elving Jolanda J   Jääskeläinen Anne J AJ   Jancauskaite Ruta R   Keeren Kathrin K   Fischer Thea K TK   Krokstad Sidsel S   Nikolaeva-Glomb Lubomira L   Novakova Ludmila L   Midgley Sofie E SE   Mirand Audrey A   Molenkamp Richard R   Morley Ursula U   Mossong Joël J   Muralyte Svajune S   Murk Jean-Luc JL   Nguyen Trung T   Nordbø Svein A SA   Österback Riikka R   Pas Suzan S   Pellegrinelli Laura L   Pogka Vassiliki V   Prochazka Birgit B   Rainetova Petra P   Van Ranst Marc M   Roorda Lieuwe L   Schuffenecker Isabelle I   Schuurman Rob R   Stoyanova Asya A   Templeton Kate K   Verweij Jaco J JJ   Voulgari-Kokota Androniki A   Vuorinen Tytti T   Wollants Elke E   Wolthers Katja C KC   Zakikhany Katherina K   Neher Richard R   Harvala Heli H   Simmonds Peter P  

Emerging infectious diseases 20210601 6


In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual  ...[more]

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